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Diabetes: scientists discover new possible treatments to limit collateral damage of insulin

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A group of researchers at the University of Geneva has identified proteins that can function as regulators of blood glucose and lipids under certain conditions. This protein, called S100A9, may counteract the side effects of insulin given to diabetics.

This study, published at Nature Communications, has the potential to be a new treatment for diabetes and generally states that it can significantly improve the quality of daily life of tens of millions of people.

In fact, millions of people must use insulin injections for both type 1 and type 2 diabetes. Overdose can cause hypoglycemia and lower blood sugar, but overdose is also dangerous for high blood sugar.

Scientists have found in mice that improved glucose management and better control of ketones and lipids can be achieved by administering S100A9 to diabetic insulin-deficient rats. They then discovered that this protein seems to work only when there is TLR4, a receptor located in the membranes of certain cells, including adipocytes and cells of the immune system.

Currently, Roberto Coppari, one of the authors of the study with Giorgio Ramadori, is working with his team to understand the function of the S100A9 protein. In this regard, they have devised a new treatment that combines S100A9 with a low dose of insulin and understands whether it can better control glucose and ketones and limit the same negative side effects of insulin.

“We also want to decipher the exact role of TLR4 to provide a therapeutic strategy that achieves the delicate balance of optimal blood sugar, ketone and lipid control,” Coppari explains in a press release.


Related articles & sources:

https://www.unige.ch/communication/communiques/en/2019/diabete-des-traitements-de-nouvelle-generation-bientot-disponibles/

https://www.nature.com/articles/s41467-019-11498-x

Image Souce:

https://www.medicalnewstoday.com/content/images/articles/321/321097/a-doctor-writing-the-word-diabetes.jpg

John Mitchell

I am a senior Python and Flask developer, currently working in silicon valley for a major tech company. During my spare time, I will contribute to Xaski News to report on different scientific research that I find interesting. I am an avid reader of many different publications including Cosmos, Popular Mechanics and Scientific American.

2038 Ella Street, San Francisco California, 94143
[email protected]
415-560-6512
John Mitchell
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Science

Scientists study genes regulating dog coat colours

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Studying a breed of Irish setter, a study team at UC Davis School of Veterinary Medicine discovered a new genetic element that underlies the regulation of coat color in dogs. Specifically, the researchers studied the Nova Scotia Duck Tolling Retriever, a medium-sized hunting dog, often referred to as a toller.

According to the researchers, the particular color of the coat of these dogs derives from two particular pigments, yellow (pheomelanin) and black (eumelanin). These two pigments, in turn, are regulated by the MC1R genes (melanocortin receptor 1) and the agouti signaling protein (ASIP). Depending on the mutation of MC1R, the coat of these dogs may produce more or less pheomelanin and appear more or less yellow or red.

Specifically, dogs with a larger number of copies of the DNA region on chromosome 15 have more intense coat colors while animals with a smaller number of copies have a lighter coat.

The study, which appeared in Genes, shows how much there is still to know about the different coat colours of dogs, even of other breeds. The study was carried out by senior author Danika Bannasch and graduate student Kalie Weich.

John Mitchell

I am a senior Python and Flask developer, currently working in silicon valley for a major tech company. During my spare time, I will contribute to Xaski News to report on different scientific research that I find interesting. I am an avid reader of many different publications including Cosmos, Popular Mechanics and Scientific American.

2038 Ella Street, San Francisco California, 94143
[email protected]
415-560-6512
John Mitchell
Continue Reading

Science

According to a famous designer, future architects will be useless due to artificial intelligence

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According to New York designer Sebastian Errazuriz, architects are among the many occupations and activities that could be literally replaced by advances in technology related to artificial intelligence. Architect and designer Elaziriz later made these statements into a series of films published on his Instagram account and later covered them in a statement.

According to ErraZuriz, it is almost impossible for an architect to compete with an artificial intelligence algorithm, and this will become a reality in the near future, so the architect himself said that “90% of the work is at risk. It is important to warn of this as soon as possible.”

In this regard, in one of the Instagram posts, the designer released an animation developed by new software that can generate building plans in a fully automated way. And this is what can happen today. Imagine this kind of technology 1000 times more powerful now.

Machine learning is becoming more and more proficient, and software can literally store large amounts of data and knowledge related to building technology in seconds. In the future, Ella Zuriz predicts that by setting various features such as budget, size, etc., getting a project in seconds will give customers more details about the type of building they want.

The same customer can “visit” the building through augmented reality technology, even before the foundation is built.

According to Elaziriz, the only architect who will survive are architects practicing architecture as an art, but that is a small elite, and at best only 1% of all architects. Everything else is doomed.


Related articles & sources:

https://www.dezeen.com/2019/10/22/artificial-intelligence-ai-architects-jobs-sebastian-errazuriz/

https://en.wikipedia.org/wiki/Sebastian_ErraZuriz

https://www.instagram.com/tv/B3jzjj0joCf/

Image Souce:

http://futurearchitectureplatform.org/media/froala/ai-1.jpg

John Mitchell

I am a senior Python and Flask developer, currently working in silicon valley for a major tech company. During my spare time, I will contribute to Xaski News to report on different scientific research that I find interesting. I am an avid reader of many different publications including Cosmos, Popular Mechanics and Scientific American.

2038 Ella Street, San Francisco California, 94143
[email protected]
415-560-6512
John Mitchell
Continue Reading

Science

Arctic permafrost: imminent thawing more serious than previously thought

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Scientists have repeatedly mentioned the dangers associated with melting Arctic permafrost. This type of soil is a risk that stems from the fact that it is a truly massive carbon deposit that increases dramatically when released into the environment and has unpredictable effects. The amount of carbon dioxide in the air further accelerates the ongoing global warming process.

A new warning has been issued, published today at Nature Climate Change. This is a study with a decisive tone, saying that permafrost is melting more and more in the northern part of the planet, and is probably releasing much more carbon than previously calculated. The same researchers predict that CO2 emissions in the environment will increase by 17% “in moderate mitigation scenarios” until 2100.

Permafrost carbon network researchers analyzed more than 100 sites in the Arctic and estimated that permafrost released an average of 1662 teragrams of carbon in the winter of 2003-2017. This is far more than previous studies had estimated.

And due to the lack of sites considered in view of the vastness of areas where permafrost is expanding, it is still a limited study. For example, if you consider the entire Arctic, the results can be even more alarming.


Related articles & sources:

https://www.sciencemag.org/news/2019/10/global-impacts-thawing-arctic-permafrost-may-be-imminent

https://www.nature.com/articles/s41558-019-0592-8

Image Souce:

https://cdn.vox-cdn.com/thumbor/QdWnGSo-CZ6WPbTEE0X-gH47zNw=/0x0:4240×2478/1200×0/filters:focal(0x0:4240×2478):no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/9107721/DSC00291.jpg

John Mitchell

I am a senior Python and Flask developer, currently working in silicon valley for a major tech company. During my spare time, I will contribute to Xaski News to report on different scientific research that I find interesting. I am an avid reader of many different publications including Cosmos, Popular Mechanics and Scientific American.

2038 Ella Street, San Francisco California, 94143
[email protected]
415-560-6512
John Mitchell
Continue Reading

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